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Dr. André Estevez-Torres, CNRS and Sorbonne Université, Paris

Pattern formation by design in DNA reaction-diffusion systems and active gels
Wann 13.05.2019
von 14:00 bis 15:00
Wo Hörsaal Makro
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The question that motivates my research is to understand to what extent molecular systems can create spatial order at the macroscopic scale. In an attempt to answer this question, we engineer non-equilibrium molecular systems that mimic some of the basic processes taking place during early embryo development, of which I will discuss two very simplified realizations. Firstly, I will show how to program DNA/enzyme reaction networks to generate reaction-diffusion patterns, such as travelling waves and band patterns [1]. Secondly, I will introduce an active gel, made of protein motors and filaments, that generates static corrugated patterns of tunable wavelength [2]. I will end by discussing how one can exploit these two processes for devising synthetic materials inspired from embryonic development.

[1] Zadorin AS, et al (2017) Synthesis and materialization of a reaction–diffusion french flag pattern. Nature Chemistry 9:990.

[2] Senoussi A, et al (2019) Tunable corrugated patterns in an active gel sheet, arXiv:1904.09249

 

Organisation:
Institut für MAkromolekulare Chemie
Stefan-Meier-Str. 31
79104 Freiburg