Dr. Kensuke Osada, Institute for Quantum Life Science, National Institutes for Quantum and Radiological Science and Technology, Japan

Control of versatile higher-ordered structures of pDNA by block copolymers and their application as gene delivery system

Wann	03.09.2019 von 16:15 bis 17:15
Wo	Hörsaal Makro
Termin übernehmen	vCal iCal

DNA folding is a core phenomenon in genome packaging within a nucleus. In principle, this is a polyion complexion formed between DNA and polycations. Block catiomers composed of a polycation and a hydrophilic polymer, most typically poly(ethylene glycol) (PEG), allow single-molecule DNA for folding within the spontaneously formed polyplex micellar structure, eventually exhibiting several higher-ordered structures including rod-shape, globular, and ring-shape (toroid) structures. This talk discusses the origin of these versatile higher-ordered structure formations when and how DNA is organized into these structures upon complexation with block catiomers, and also addresses the utility of the polyplex micelles as a potent gene vector for challenging cancer particularly focusing on intractable pancreatic tumor.1
1) H. Cabral, K. Miyata, K. Osada, K. Kataoka, Block copolymer micelles in nanomedicine applications. Chemical Review 118 6844-6892 (2018)

Host:
Prof. A. Walther